abstract：:Age-related changes in cancer mortality risk are important for understanding the processes of disease and aging interaction. The extent to which these age changes differ by sex further contributes to this understanding but has not been well studied to date. We conducted a systematic examination of dynamics and heterog...

journal_title：Experimental gerontology

authors： Yang Y,Li T,Nielsen ME

更新日期：2012-09-01 00:00:00

abstract：:Increased lifespan can be associated with greater resistance to many different stressors, most notably thermal stress. Such hormetic effects have also been found in C. elegans where short-term exposure to heat lengthens the lifespan. Genetic investigations have been carried out using mutation perturbations in a single...

journal_title：Experimental gerontology

authors： Rodriguez M,Snoek LB,Riksen JA,Bevers RP,Kammenga JE

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:To examine the individual association between BMI and level of serum uric acid (SUA) among the very elderly Chinese population. METHODS:A survey was conducted on 870 long-lived subjects (aged ≥90years). Subjects were divided into four groups according to quartile of BMI (<16.6, 16.6-18.9, 18.9-21.1, ≥21.1kg...

journal_title：Experimental gerontology

authors： Yue JR,Huang CQ,Dong BR

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The cortisol awakening response (CAR) is a useful endocrine marker for the hypothalamic-pituitary-adrenal axis activity. Recent studies suggest that the cortisol level influences the expression of the hPER1 clock gene which is involved in the generation of biological rhythms. This study aimed t...

journal_title：Experimental gerontology

authors： Olbrich D,Dittmar M

更新日期：2012-07-01 00:00:00

abstract：:Changes associated with the age-related decline of physiological functions, and their relation with mortality rates, are thoroughly being investigated in the aging research field. We used the Mediterranean fruit fly Ceratitis capitata, largely studied by biodemographers, as a model for functional senescence studies. T...

journal_title：Experimental gerontology

authors： Pujol-Lereis LM,Rabossi A,Quesada-Allué LA

更新日期：2012-06-01 00:00:00

abstract：:Despite general belief that the mechanical properties of bone material contribute to whole bone strength, it is still obscure what the age effects are on mechanical behavior of the bone material, particularly in the case of the femoral neck trabeculae. In this study, atomic force microscopy was used for imaging and me...

journal_title：Experimental gerontology

authors： Milovanovic P,Potocnik J,Djonic D,Nikolic S,Zivkovic V,Djuric M,Rakocevic Z

更新日期：2012-02-01 00:00:00

abstract：:Post-translational oxidative protein modifications which are more marked during aging and/or high-calorie (HC) diets affect protein function and metabolism. Protein function and metabolism are different according to the type of muscle proteins. Oxidative muscle protein modifications may thus be associated with age-rel...

journal_title：Experimental gerontology

authors： Murakami H,Guillet C,Tardif N,Salles J,Migné C,Boirie Y,Walrand S

更新日期：2012-02-01 00:00:00

abstract：:As a major intracellular source of reactive oxygen species (ROS), mitochondria are involved in aging and lifespan regulation. Using the yeast chronological aging model, researchers have identified conserved signaling pathways that affect lifespan by modulating mitochondrial functions. Caloric restriction and a genetic...

journal_title：Experimental gerontology

authors： Pan Y

更新日期：2011-11-01 00:00:00

abstract：:There is growing concern over the increasing instances of decline in cognitive abilities with aging in humans. The present study evaluated the benefits of the natural antioxidant, grape seed proanthocyanidin extract (GSPE) in treating the effects of age-related oxidative stress (OS) and accumulation of lipofuscin (LF)...

journal_title：Experimental gerontology

authors： Asha Devi S,Sagar Chandrasekar BK,Manjula KR,Ishii N

更新日期：2011-11-01 00:00:00

abstract：:Forkhead box O 3a (FoxO3a) has been known to link with aging process and senescence. In this study, we investigated the age-related changes of FoxO3a in the gerbil hippocampus using immunohistochemistry and western blot analysis. In the postnatal month 3 (PM 3) group, FoxO3a immunoreactivity was well detected in pyram...

journal_title：Experimental gerontology

authors： Park JH,Lee CH,Yoo KY,Choi JH,Hwang IK,Lee JY,Kang IJ,Won MH

更新日期：2011-10-01 00:00:00

abstract：:To explore the relationship between age-related hearing loss (presbycusis) and synaptic degeneration in the hippocampal CA3 region of C57BL/6J mice, we investigated both cognitive performance and synaptic changes within the hippocampus of C57BL/6J mice from three age groups of 6-8, 24-26, and 42-44 weeks; CBA/CaJ mice...

journal_title：Experimental gerontology

authors： Yu YF,Zhai F,Dai CF,Hu JJ

更新日期：2011-09-01 00:00:00

abstract：:Aging is associated with an increased incidence of heart failure, but the existence of an age-related cardiomyopathy remains controversial. Differences in strain, age and technique of measuring cardiac function differ between experiments, confounding the interpretation of these studies. Additionally, the structural an...

journal_title：Experimental gerontology

authors： Boyle AJ,Shih H,Hwang J,Ye J,Lee B,Zhang Y,Kwon D,Jun K,Zheng D,Sievers R,Angeli F,Yeghiazarians Y,Lee R

更新日期：2011-07-01 00:00:00

abstract：:Apolipoprotein E knockout (apoE-KO) mice have been utilized for decades as a model of atherosclerosis. However, in addition to atherosclerosis, apoE-KO mice develop extensive cutaneous xanthomatosis, accelerated skin aging and frailty when fed a high fat diet. Granzyme B (GrB) is a pro-apoptotic serine protease that h...

journal_title：Experimental gerontology

authors： Hiebert PR,Boivin WA,Abraham T,Pazooki S,Zhao H,Granville DJ

更新日期：2011-06-01 00:00:00

abstract：:The abundance of a selection of transcript species involved in inflammation, immunosenescence and stress response was compared between PBMC of 35 geriatric patients with hip fracture in acute phase (days 2-4 after hospitalization) or convalescence phase (days 7-10) and 28 healthy aged controls. Twenty-nine differentia...

journal_title：Experimental gerontology

authors： Vo TK,Godard P,de Saint-Hubert M,Morrhaye G,Debacq-Chainiaux F,Swine C,Geenen V,Martens HJ,Toussaint O

更新日期：2011-04-01 00:00:00

abstract：:A non-enzymatic reaction between ketones or aldehydes and the amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and to the development and progression of various age-related disorders such as vascular complications of diabetes, Alzheimer's disease, cancer growth and metastas...

journal_title：Experimental gerontology

authors： Yamagishi S

更新日期：2011-04-01 00:00:00

abstract：:The achievement that cytokines and all the related "transducing machinery" are expressed within the central nervous system and play a consistent role in the modulation of neurological functions and dysfunctions, has allowed a novel interpretation of brain behaviour. In this view, neuroinflammation and cytokines produc...

journal_title：Experimental gerontology

authors： Viviani B,Boraso M

更新日期：2011-02-01 00:00:00

abstract：:The major neuroendocrine response mediating stress adaptation is activation of the hypothalamic pituitary adrenal axis, with stimulation of corticotropin releasing hormone (CRH) and vasopressin (VP) from parvocellular neurons of the hypothalamic paraventricular nucleus, leading to stimulation of pituitary ACTH secreti...

journal_title：Experimental gerontology

authors： Aguilera G

更新日期：2011-02-01 00:00:00

abstract：:The purpose of this study was to examine the combined cardiorespiratory and cerebrovascular responses to head-up tilt (HUT) in young and older trained and untrained humans following moderate-duration exercise. Middle cerebral artery blood flow velocity (MCAv; transcranial Doppler ultrasound), blood pressure (BP; Finom...

journal_title：Experimental gerontology

authors： Murrell CJ,Cotter JD,George K,Shave R,Wilson L,Thomas K,Williams MJ,Ainslie PN

更新日期：2011-01-01 00:00:00

abstract：:There is growing concern over the increasing use of opioids to treat chronic pain in the elderly primarily because of the potential increased sensitivity to the adverse side effects. Here, we use a preclinical model (male Brown Norway X F344 rats aged 12, 18, 24, and 30 months) to describe the outcome of chronic fenta...

journal_title：Experimental gerontology

authors： Mitzelfelt JD,Dupree JP,Seo DO,Carter CS,Morgan D

更新日期：2011-01-01 00:00:00

abstract：:It has been suggested that alterations in Na(+),K(+)-ATPase mediate the development of several aging-related pathologies, such as hypertension and diabetes. Thus, we evaluated Na(+),K(+)-ATPase function and H(2)O(2) production in the renal cortex and medulla of Wistar Kyoto (WKY) rats at 13, 52 and 91 weeks of age. Cr...

journal_title：Experimental gerontology

authors： Silva E,Pinto V,Simão S,Serrão MP,Afonso J,Amaral J,Pinho MJ,Gomes P,Soares-da-Silva P

更新日期：2010-12-01 00:00:00

abstract：:Inducible nitric oxide synthase (iNOS) is involved in obesity-induced insulin resistance. Since aging is accompanied by increased iNOS expression, the effect of iNOS gene deletion on aging-associated insulin resistance was investigated in 7-month-old (adult) and 22-month-old (old) iNOS knockout and wild-type mice usin...

journal_title：Experimental gerontology

authors： Cha HN,Kim YW,Kim JY,Kim YD,Song IH,Min KN,Park SY

更新日期：2010-09-01 00:00:00

abstract：:Mitochondrial superoxide production is an important source of reactive oxygen species in cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites of superoxide production in mammalian mitochondria are known and widely accepted. In descending order of maximum capacity they are the ubiq...

journal_title：Experimental gerontology

authors： Brand MD

更新日期：2010-08-01 00:00:00

abstract：:The cold-induced enhancement of non-shivering thermogenesis (NST), involving brown-adipose tissue (BAT) metabolism, could participate to impair energy balance in the aged gray mouse lemur (Microcebus murinus). We first investigated the age-related modulations of cold-stimulated BAT cell morphology and contents. Then, ...

journal_title：Experimental gerontology

authors： Terrien J,Ambid L,Nibbelink M,Saint-Charles A,Aujard F

更新日期：2010-06-01 00:00:00

abstract：:Aging is one of the most basic properties of living organisms. Abundant evidence supports the idea that cell senescence underlies organismal aging in higher mammals. Therefore, examining the molecular mechanisms that control cell and replicative senescence is of great interest for biology and medicine. Several discove...

journal_title：Experimental gerontology

authors： Vidacek NS,Cukusić A,Ivanković M,Fulgosi H,Huzak M,Smith JR,Rubelj I

更新日期：2010-03-01 00:00:00

abstract：:Age-related changes of gene expression contribute to the physiological alteration observed with human ageing. Herein, the abundance of a selection of 148 transcripts involved in immunosenescence and stress response was compared in total RNA of PBMC of healthy young to middle-age probands (35.0 +/- 6.5 year old) and he...

journal_title：Experimental gerontology

authors： Vo TK,Godard P,de Saint-Hubert M,Morrhaye G,Bauwens E,Debacq-Chainiaux F,Glupczynski Y,Swine C,Geenen V,Martens HJ,Toussaint O

更新日期：2010-03-01 00:00:00

abstract：:Coronary heart disease is less prevalent in pre-menopausal women than in men, but increases at the onset of menopause. This delay is due to estrogen protective effects. The rise of cholesterolemia is one of the main risk factors for coronary disease. Since 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the ...

journal_title：Experimental gerontology

authors： Trapani L,Violo F,Pallottini V

更新日期：2010-02-01 00:00:00

abstract：:Advances in our understanding of tau-mediated neurodegeneration in Alzheimer's disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. Immunoassays were developed detecting total (t-tau) and tau phosphorylated at specific epitopes (p-...

journal_title：Experimental gerontology

authors： Hampel H,Blennow K,Shaw LM,Hoessler YC,Zetterberg H,Trojanowski JQ

更新日期：2010-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive neurodegenerative disorder with characteristic neuropathological features that are accompanied by inflammatory processes and release of pro-inflammatory cytokines. There is evidence that microglial cells are a key mediator of damage in AD. The microglial compartment may arise ...

journal_title：Experimental gerontology

authors： Hochstrasser T,Weiss E,Marksteiner J,Humpel C

更新日期：2010-01-01 00:00:00

abstract：:A correct clinical diagnosis in the early stage of Alzheimer Disease (AD) is mandatory given the current available treatment with acetylcholine esterase inhibitors. Moreover, a early to preclinical diagnosis would allow to identify patients eligible for future disease-modifying therapies. In the last ten years, we hav...

journal_title：Experimental gerontology

authors： Borroni B,Agosti C,Marcello E,Di Luca M,Padovani A

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Depression is common in hemodialysis patients. Reduced DHEA-S levels have been shown to be associated with depression in general population. Abnormalities in hormone production and metabolism are found in hemodialysis patients. However, the association between DHEA-S levels and depression in hemodialysis pati...

journal_title：Experimental gerontology

authors： Hsu HJ,Chen CK,Hsiao CC,Wu IW,Sun CY,Chou CC,Lee CC,Tsai CJ,Wu MS

更新日期：2009-11-01 00:00:00

abstract：:Calorie restriction (CR) and a reduced growth hormone (GH) signal affect insulin sensitivity and lifespan in mammals in a similar manner. We investigated the effects of CR and moderate inhibition of GH on glucose-stimulated activation of insulin signaling and the expression of genes related to fat metabolism in white ...

journal_title：Experimental gerontology

authors： Park S,Komatsu T,Hayashi H,Trindade LS,Yamaza H,Chiba T,Shimokawa I

更新日期：2009-10-01 00:00:00

abstract：:Aging plays an important role in increased vulnerability to atrial fibrillation (AF). Mediated by activity at the muscarinic type 2 receptor (M2R), the parasympathetic nerve contributes to the onset of AF. The purpose of this study was to investigate whether aging changes the distribution of M2R in the atrial myocardi...

journal_title：Experimental gerontology

authors： Yang YH,Zheng QS,Li J,Shang FJ,Liu T,Wang HT,Liu XT,Liu L

更新日期：2009-09-01 00:00:00

abstract：:Male life history and resource allocation is not frequently studied in aging and life span research. Here, we verify that males of long-lived fruit-feeding butterfly species have reduced longevity on restricted diets [Beck, J., 2007. The importance of amino acids in the adult diet of male tropical rainforest butterfli...

journal_title：Experimental gerontology

authors： Molleman F,Ding J,Boggs CL,Carey JR,Arlet ME

更新日期：2009-09-01 00:00:00

abstract：:Telomerase plays an important role in cellular proliferation capacity and survival under conditions of stress. A large part of this protective function is due to telomere capping and maintenance. Thus it contributes to cellular immortality in stem cells and cancer. Recently, evidence has accumulated that telomerase ca...

journal_title：Experimental gerontology

authors： Saretzki G

更新日期：2009-08-01 00:00:00

abstract：:Aromatase inhibitors have become the standard of care for the adjuvant treatment of postmenopausal, hormone-sensitive breast cancer. Meanwhile, more and more breast cancer patients who are treated with aromatase inhibitors as adjuvant therapies often experience arthralgias and musculoskeletal aching, in some cases, ha...

journal_title：Experimental gerontology

authors： Wang J,Zhang Q,Jin S,Feng M,Kang X,Zhao S,Liu S,Zhao W

更新日期：2009-06-01 00:00:00

abstract：:There is accumulating evidence that oxidative stress plays an important role in aging. Our previous phosphoproteomic study of the human neuroblastoma cell line SH-SY5Y revealed changes in the phosphorylation of several proteins such as lamin A/C during 6-hydroxydopamine-induced oxidative stress. The present study empl...

journal_title：Experimental gerontology

authors： Nakamura M,Morisawa H,Imajoh-Ohmi S,Takamura C,Fukuda H,Toda T

更新日期：2009-06-01 00:00:00

abstract：:To study the several elements and causes of ageing, diverse model organisms and methodologies are required. The most frequently used models are Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster and rodents. All have their advantages and disadvantages and allow studying particular aspects of the...

journal_title：Experimental gerontology

authors： Mouton S,Willems M,Braeckman BP,Egger B,Ladurner P,Schärer L,Borgonie G

更新日期：2009-04-01 00:00:00

abstract：:The APOE epsilon4 allele has been associated with a number of neurodegenerative disorders e.g. Alzheimer's disease. Inconsistent results have been obtained for cognitive decline in 'normal' aging. We investigated whether specific aspects of cognitive decline were associated with APOE epsilon4 among 620 'healthy' elder...

journal_title：Experimental gerontology

authors： De Blasi S,Montesanto A,Martino C,Dato S,De Rango F,Bruni AC,Mari V,Feraco E,Passarino G

更新日期：2009-03-01 00:00:00

abstract：:Intracellular Ca(2+) signaling is important to perfusion pressure related arterial reactivity and to vascular disorders including hypertension, angina and ischemic stroke. We have recently shown that advancing-age leads to calcium signaling adaptations in mesenteric arterial myocytes from C57 BL/6 mice [Corsso, C.D., ...

journal_title：Experimental gerontology

authors： Goyal R,Angermann JE,Ostrovskaya O,Buchholz JN,Smith GD,Wilson SM

更新日期：2009-03-01 00:00:00

abstract：:Engineering of fetal tissue has a high potential for the treatment of acute and chronic wounds of the skin in humans as these cells have high expansion capacity under simple culture conditions and one organ donation can produce Master Cell Banks which can fabricate over 900 million biological bandages (9 x 12cm). In a...

journal_title：Experimental gerontology

authors： Ramelet AA,Hirt-Burri N,Raffoul W,Scaletta C,Pioletti DP,Offord E,Mansourian R,Applegate LA

更新日期：2009-03-01 00:00:00